American Chemical Society
ol500173y_si_001.pdf (2.28 MB)

Absolute Configuration Determination Using Enantiomeric Pairs of Molecularly Imprinted Polymers

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journal contribution
posted on 2014-03-07, 00:00 authored by Danielle S. Meador, David A. Spivak
A new method for determination of absolute configuration (AC) is demonstrated using an enantiomeric pair of molecularly imprinted polymers, referred to as “DuoMIPs”. The ratio of HPLC capacity factors (k′) for the analyte on each of the DuoMIPs is defined as the γ factor and can be used to determine AC when above 1.2. A mnemonic based on the complementary binding geometry of the DuoMIPs was used to aid in understanding and prediction of AC.