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A Versatile Approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from l-(−)-Quebrachitol

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journal contribution
posted on 22.12.1999, 00:00 by Lixin Qiao, Youhong Hu, Fajun Nan, Garth Powis, Alan P. Kozikowski
A versatile synthesis of PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 is disclosed, starting from l-(−)-quebrachitol, a byproduct of latex production. The crystalline nature of most intermediates and the utilization of inexpensive protecting groups facilitate this synthetic route and its scale-up.