Despite
the fact that chemotherapy has been widely used in the
clinical treatment of breast cancer, the toxicity of chemotherapeutics
to normal tissues cannot be ignored due to the low specificity. Therefore,
due to the non-negligible toxicity of chemotherapeutic agents to normal
tissues, tumor microenvironment (TME)-responsive cancer therapy has
attracted a great deal of attention. Here, we report a TME-responsive
theranostic nanoagent MnOx@PAA@HKUST-1-DSF@BSA fabricated via a layer-by-layer
synthesis method. Once endocytosed by tumor cells, the nanoagent can
be degraded into Mn2+ for magnetic resonance imaging and
Cu2+ for Fenton-like reaction and chelating with released
disulfiram in situ, achieving enhanced chemotherapy. Both in vitro
and in vivo experiments demonstrate that the TME-targeted nanoagent
can efficiently kill tumor cells. This work provides an alternative
option for effective imaging and treatment of breast cancer without
collateral damage to normal tissues.