A Third Generation Potentially Bifunctional Trithiol
Chelate, Its nat,1XXSb(III) Complex, and Selective Chelation
of Radioantimony (119Sb) from Its Sn Target
posted on 2021-10-04, 18:41authored byAeli P. Olson, Li Ma, Yutian Feng, Firouzeh Najafi Khosroshahi, Steven P. Kelley, Eduardo Aluicio-Sarduy, Todd E. Barnhart, Heather M. Hennkens, Paul A. Ellison, Silvia S. Jurisson, Jonathan W. Engle
The
therapeutic potential of the Meitner-Auger- and conversion-electron
emitting radionuclide 119Sb remains unexplored because
of the difficulty of incorporating it into biologically targeted compounds.
To address this challenge, we report the development of 119Sb production from electroplated tin cyclotron targets and its complexation
by a novel trithiol chelate. The chelation reaction occurs in harsh
solvent conditions even in the presence of large quantities of tin,
which are necessary for production on small, low energy (16 MeV) cyclotrons.
The 119Sb-trithiol complex has high stability and can be
purified by HPLC. The third generation trithiol chelate and the analogous
stable natSb-trithiol compound were synthesized and characterized,
including by single-crystal X-ray diffraction analyses.