ol7b01374_si_001.pdf (5.68 MB)
A Tandem Oxidative Annulation Strategy for the Synthesis of Tetracyclic 3‑Spirooxindole Benzofuranones
journal contribution
posted on 2017-06-23, 12:37 authored by Chunxia Zhang, Min Liu, Mingruo Ding, Hao Xie, Fengzhi ZhangA simple and efficient method was
developed for the construction
of the medicinally important tetracyclic 3-spirooxindole benzofuranones.
In this highly atom- and step-economical one-pot protocol, one quaternary
carbon center, two new cycles, and four new bonds (C–C/C–O/C–N)
were formed under simple ligand-free copper-catalyzed conditions through
a novel tandem oxidative annulation strategy.