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A Synthesis of the Welwistatin Core§

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journal contribution
posted on 09.11.2006, 00:00 by Ryan Lauchli, Kenneth J. Shea
An approach to the core structure of the microtubule-targeting agent welwistatin is described. The approach utilizes the type 2 intramolecular Diels−Alder reaction, with indole serving as the tether between diene and dienophile, to form the natural product's characteristic bicyclo[4.3.1]decane skeleton.