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A Synthesis of Multifunctionalized Indoles from [3 + 2] Annulation of 2‑Bromocyclo­propenes with Anilines

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journal contribution
posted on 14.05.2019, 20:10 by Zhu Cao, Jian-Bo Zhu, Lijia Wang, Saihu Liao, Yong Tang
A new regioselective method for the synthesis of multifunctionalized indoles from [3 + 2] annulation of 2-bromocyclopropenes with anilines has been developed. By employing a nickel complex as a catalyst, 27 examples of indole products were obtained in good yields with excellent regioselectivity. Synthetic utility of the resulting product was demonstrated in a concise synthesis of biologically active compound Paullone.