A Strategy to Synthesize Taxol Side Chain and (−)-epi Cytoxazone via Chiral Brønsted Acid-Rh2(OAc)4 Co-catalyzed Enantioselective Three-Component Reactions
journal contributionposted on 05.11.2010, 00:00 by Yu Qian, Xinfang Xu, Liqin Jiang, Dipak Prajapati, Wenhao Hu
A new approach to synthesize optically active β-amino-α-hydroxyl acid derivatives via chiral Brønsted acid-Rh2(OAc)4 cocatalyzed three-component reactions of diazo acetates with alcohols and imines is reported. A matched reaction system was identified to give the products in moderate diastereoselectivity and good enantioselectivity. Application of this methodology is demonstrated in the efficient synthesis of a taxol side chain and (−)-epi-cytoxazone.