A Soluble Copper(I) Source and Stable Salts of Volatile Ligands for Copper-Catalyzed C–X Couplings

A stable adduct of CuI with Bu₄NI, soluble in organic solvents, has been identified as an effective catalyst for copper-catalyzed C–N and C–O couplings. In addition, stable nonhygroscopic salts of some high performance ligands (diamine MsOH salts/CuX and copper­(II) diketonates) were shown to be of similar and sometimes greater reactivity compared to the literature reagents for these couplings. Furthermore, these more robust conditions result in more reproducible results.