jo034545y_si_002.pdf (40.73 kB)
A Short and Efficient Synthesis of Crocetin-dimethylester and Crocetindial
journal contribution
posted on 2003-10-23, 00:00 authored by Daniel Frederico, Paulo Marcos Donate, Mauricio Gomes Constantino, Erika Soares Bronze, Mirela I. SairreIn this paper we describe an efficient six-step
synthesis of crocetin-dimethylester that could be further
reduced to a “four-step” synthesis through the use of in situ
procedures. The simplicity of the whole process, the ready
availability of starting materials, and the high overall yield
render this strategy a very attractive synthesis of this very
important compound, which is the key intermediate for the
synthesis of several carotenoids and other polyene natural
products.