A Short Total Synthesis of (+)-Furanomycin

Furanomycin is a <i>Streptomyces</i> metabolite that substitutes for isoleucine in protein translation. We report a concise and modular synthesis starting from the Garner aldehyde and proceeding in seven steps to furanomycin. The key steps include a stereoselective acetylide addition and the Ag⁺-mediated cyclization of an α-allenic alcohol to construct the <i>trans</i>-2,5-dihydrofuran. The efficiency (12% overall yield) and flexibility of the route will provide ample quantities of furanomycin and analogues for protein engineering.