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A Short Synthesis of (±)-Epiasarinin

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journal contribution
posted on 14.03.2002, 00:00 by David J. Aldous, Anne J. Dalençon, Patrick G. Steel
Epiasarinin, an endo-endo furofuran, has been synthesized from piperonal via a five-step route with good stereocontrol. The sequence involves Darzens condensation, alkenyl epoxide−dihydrofuran rearrangement, and a Lewis acid mediated cyclization.