A Self-Assembled Delivery Platform with Post-production Tunable Release Rate
journal contributionposted on 08.08.2012, 00:00 by Job Boekhoven, Mathijs Koot, Tim A. Wezendonk, Rienk Eelkema, Jan H. van Esch
Self-assembly of three molecular components results in a delivery platform, the release rate of which can be tuned after its production. A fluorophore-conjugated gelator can be hydrolyzed by an enzyme, resulting in the release of a fluorescent small molecule. To allow the release to be tunable, the enzyme is entrapped in liposomes and can be liberated by heating the system for a short period. Crucially, the heating time determines the amount of enzyme liberated; with that, the release rate can be tuned by the time of heating.