jo5b00315_si_001.pdf (1.03 MB)
Download file

A Route to the Heterocyclic Cluster of the E‑Series of Thiopeptide Antibiotics

Download (1.03 MB)
journal contribution
posted on 17.04.2015, 00:00 by Hee-Jong Hwang, Marco A. Ciufolini
A concise route to the 3-hydroxypyridine core of thiopeptide antibiotics such as nocathiacin is described. Key phases of the sequence involve a modified Hantzsch pyridine construction and a chemoselective Peng deprotection of a phenolic MOM ether.