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A Ring Expansion–Glycosylation Strategy toward the Synthesis of Septano-oligosaccharides

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journal contribution
posted on 2012-11-02, 00:00 authored by Perali Ramu Sridhar, Patteti Venukumar
A one-pot ring-expansion–glycosylation reaction was performed using 1,2-cyclopropanated sugars as glycosyl donors and carbohydrate O-nucleophiles as acceptors to provide septanohexose mimics of pyranose and furanose derivatives. The methodology was successfully extended to the synthesis of septano-oligosaccharides by adopting a divergent strategy as well as an iterative protocol.