A Protocol To Generate Phthaloyl Peroxide in Flow for the Hydroxylation of Arenes
journal contribution
posted on 2014-07-18, 00:00 authored by Anders
M. Eliasen, Randal P. Thedford, Karin R. Claussen, Changxia Yuan, Dionicio SiegelA flow protocol for
the generation of phthaloyl peroxide has been
developed. This process directly yields phthaloyl peroxide in high
purity (>95%) and can be used to bypass the need to isolate and
recrystallize
phthaloyl peroxide, improving upon earlier batch procedures. The flow
protocol for the formation of phthaloyl peroxide can be combined with
arene hydroxylation reactions and provides a method for the consumption
of peroxide as it is generated to minimize the accumulation of large
quantities of peroxide.
