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A Practical Synthesis of α-Aryl Methyl Ketones via a Transition-Metal-Free Meerwein Arylation

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journal contribution
posted on 02.03.2007, 00:00 by Carmela Molinaro, Jeffrey Mowat, Francis Gosselin, Paul D. O'Shea, Jean-François Marcoux, Rémy Angelaud, Ian W. Davies
We report herein a simple, scalable, transition-metal-free approach to the synthesis of α-aryl methyl ketones from diazonium tetrafluoroborate salts under mild conditions. This methodology uses easily accessible and nontoxic starting material and was applied to the multi-kilogram-scale preparation of 1-(3-bromo-4-methylphenyl)propan-2-one.