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A Possible Infinite Number of Components in a Single Crystalline Phase: On the Isomorphism of Brivaracetam–Guest Molecules

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posted on 2018-08-20, 00:00 authored by Nicolas Couvrat, Morgane Sanselme, Yohann Cartigny, Frederic De Smet, Sandrine Rome, Luc Aerts, Luc Quéré, Johan Wouters, Gérard Coquerel
This article highlights the unusual behavior of brivaracetam (BRV: an active pharmaceutical ingredient against epilepsy), which leads to a unique phaseranging from clathrate to solvate to cocrystalformed with an impressive number of apolar guest molecules (any linear alkanes to esters of fatty acids/alcohols, or waxes). Moreover, the investigation of binary systems between linear alkanes and BRV displayed the systematic existence of a syntectic invariant (one solid melts into two nonmiscible liquids) for CnH2n+2 with n > 7.