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A Plasticizer-Free Miniaturized Optical Ion Sensing Platform with Ionophores and Silicon-Based Particles
journal contribution
posted on 2018-04-13, 00:00 authored by Xinfeng Du, Liyuan Yang, WenChang Hu, Renjie Wang, Jingying Zhai, Xiaojiang XieNanoscale ionophore-based ion-selective
optodes (nano-ISOs) are
effective sensing tools for in situ and real time measurements of
ion concentrations in biological and environmental samples. While
searching for novel sensing materials, nano-ISOs free of plasticizers
are particularly important for biological and environmental applications.
This work described plasticizer-free nano-ISOs based on Si-containing
particles including PEGylated organosilica nanoparticles, PDMS nanospheres,
and SiO2 microspheres, with diameters around 50 nm, 100
nm, and 5 μm, respectively. The platform enabled the use of
highly selective ionophores, where the nanomatrices played important
roles in tuning the ion-carrier complex formation constants and led
to better selectivity for the PEGylated organosilica nano-ISOs than
those based on PDMS. With use of the versatile silica chemistry, pH
and ion dual sensing was achieved on SiO2 microspheres.
In addition, increasing the cross-linking degree of the PDMS nano-ISOs
extended the linear response range, and cellular uptake experiments
showed that the nano-ISOs could readily enter HeLa cells with very
low cytotoxicity.
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Si-containing particles5 μ mPlasticizer-Free Miniaturized Optical IonSiO 2 microspheressilica chemistrySilicon-Based Particles Nanoscale ionophore-based ion-selective optodesresponse rangetime measurementsPEGylated organosilica nano-ISOsHeLa cells50 nmformation constantsPDMS nanospheresion concentrationsPEGylated organosilica nanoparticlesplasticizer-free nano-ISOs100 nmcross-linking degreePDMS nano-ISOsuptake experiments
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