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A One-Pot Parallel Reductive Amination of Aldehydes with Heteroaromatic Amines

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posted on 2014-08-11, 00:00 authored by Andrey V. Bogolubsky, Yurii S. Moroz, Pavel K. Mykhailiuk, Dmitriy M. Panov, Sergey E. Pipko, Anzhelika I. Konovets, Andrey Tolmachev
A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl2–TMSOAc (activating agents) and NaBH­(OAc)3 (reducing agent). A library of diverse secondary amines was easily prepared on a 50–300 mg scale.

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