A One-Pot Parallel Reductive Amination of Aldehydes
with Heteroaromatic Amines

Bogolubsky, Andrey
V.; Moroz, Yurii S.; Mykhailiuk, Pavel K.; Panov, Dmitriy M.; Pipko, Sergey E.; Konovets, Anzhelika I.; Tolmachev, Andrey

doi:10.1021/co5000568.s001

A One-Pot Parallel Reductive Amination of Aldehydes with Heteroaromatic Amines

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posted on 2014-08-11, 00:00 authored by Andrey V. Bogolubsky, Yurii S. Moroz, Pavel K. Mykhailiuk, Dmitriy M. Panov, Sergey E. Pipko, Anzhelika I. Konovets, Andrey Tolmachev

A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl₂–TMSOAc (activating agents) and NaBH(OAc)₃ (reducing agent). A library of diverse secondary amines was easily prepared on a 50–300 mg scale.

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ZnCl Aldehyde agent reductive amination Heteroaromatic AminesA Reductive Amination combination mg NaBH heteroaromatic amines

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A One-Pot Parallel Reductive Amination of Aldehydes with Heteroaromatic Amines

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