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A Novel Process for Antimalarial Drug Pyronaridine Tetraphosphate

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journal contribution
posted on 21.02.2014, 00:00 by Yu Liu, Zixue Zhang, Anfei Wu, Xiaoli Yang, Yong Zhu, Nan Zhao
A novel process for preparation of pyronaridine tetraphosphate, an antimalarial drug substance, is reported. The overall yields are 54% and >99.8% (including five chemical steps). Formation and control of possible impurities are also described.