American Chemical Society
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A Novel Palladium-Mediated Cascade Reaction Triggered by Strain Release of the Cyclobutane System. A New General Route to Benzo- and Naphthohydrindans

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journal contribution
posted on 1997-10-31, 00:00 authored by Hideo Nemoto, Junji Miyata, Masahiro Yoshida, Naomi Raku, Keiichiro Fukumoto
A novel palladium-mediated cascade reaction was reported. By this procedure, the olefinic cyclobutanols 17, 24, and 31; 41; 37; and 45 afforded the benzo- and naphthohydrindans (4649, 5053, 5457, and 5861) respectively in one operation in the ratios depending on the mediators and solvents employed. This provides a novel and efficient synthesis of biologically important A-nor and C11-alkylated steroids.