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A Noncoordinating Acid–Base Catalyst for the Mild and Nonreversible tert-Butylation of Alcohols and Phenols

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journal contribution
posted on 09.03.2021, 13:37 by Keith R. Fandrick, Nitinchandra D. Patel, Suttipol Radomkit, Arindom Chatterjee, Stefan Braith, Daniel R. Fandrick, Carl A. Busacca, Chris H. Senanayake
A mild and nonreversible tert-butylation of alcohols and phenols can be achieved in high yields using the noncoordinating acid–base catalyst [bis­(trifluoromethane)­sulfonimide and 2,6-lutidine] with a tert-butylation reagent, tert-butyl 2,2,2-trichloroacetimidate. This method allows the use of substrates containing acid sensitive groups such as ketal, Boc, and boronate esters.