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A New Strategy toward the Total Synthesis of Stachyflin, A Potent Anti-Influenza A Virus Agent:  Concise Route to the Tetracyclic Core Structure

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journal contribution
posted on 16.11.2002, 00:00 authored by Mari Nakatani, Masahiko Nakamura, Akiyuki Suzuki, Munenori Inoue, Tadashi Katoh
A new strategy directed toward the total synthesis of stachyflin, a potent and novel anti-influenza A virus agent isolated from a microorganism, has been presented through the enantioselective synthesis of the tetracyclic core structure. The synthetic method features a BF3·Et2O-induced domino epoxide-opening/rearrangement/cyclization reaction as the key step.