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A New Selective Synthesis of the Ile-allo-Thr-Gly Tripeptide Fragment of Lysobactin

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journal contribution
posted on 29.03.2000, 00:00 authored by Silvia Armaroli, Giuliana Cardillo, Luca Gentilucci, Massimo Gianotti, Alessandra Tolomelli
trans-Aziridine-2-carboxylic acid derivatives are useful intermediates for the synthesis of threonine or allo-threonine through ring expansion and SN2 displacement, respectively. We describe here the preparation of the Ile-allo-Thr-Gly 11 fragment of Lysobactin via the aziridine 9 intermediate.