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A New Polymer-Supported Reagent for the Synthesis of β-Lactams in Solution

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journal contribution
posted on 24.12.2004, 00:00 by Donato Donati, Costanza Morelli, Andrea Porcheddu, Maurizio Taddei
A modified Mukaiyama reagent was prepared on a PS-DVB resin. This reagent was used for the preparation of β-lactams, using the Staudinger reaction. The products were obtained by generating the ketene from a carboxylic acid under sonication with the resin followed by reaction with the imine. Excess of the imine was removed by reduction followed by acid scavenging.