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A New Construction of 2-Alkoxypyrans by an Acylation−Reductive Cyclization Sequence

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journal contribution
posted on 10.05.2007, 00:00 by Lars V. Heumann, Gary E. Keck
A new convergent synthetic approach to a pyran motif common to many naturally occurring structures is described. In this approach, two fragments are joined by esterification, and a subsequent intramolecular reductive cyclization affords the 2-hydroxypyran.