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A New Concise Strategy for Synthesis of Dibenzo[b,f]thiepins and Related Fused Symmetrical Thiepin Derivatives

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journal contribution
posted on 09.11.2007, 00:00 by Hamid Shirani, Tomasz Janosik
A new strategy for preparation of dibenzo[b,f]thiepins and related fused systems in good overall yields is described, featuring ortho-metalation of aromatic or heterocyclic aldehyde acetals followed by treatment with bis(phenylsulfonyl) sulfide for construction of the required bis(aryl)- or bis(heteroaryl) sulfide precursors, which were thereafter subjected to deacetalization, and finally McMurry coupling as the ring-forming step.