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A Metathesis-Based Approach to the Synthesis of 2-Pyridones and Pyridines

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journal contribution
posted on 17.01.2008, 00:00 authored by Timothy J. Donohoe, Lisa P. Fishlock, Panayiotis A. Procopiou
The ring-closing metathesis reaction has been successfully employed to form a range of dihydropyridone intermediates, which are in the correct oxidation state to undergo a base-induced elimination to reveal the aromatic 2-pyridone. This mild and novel approach to six-membered heteroaromatic compounds then provides access to a wide variety of substituted pyridines in excellent overall yield.