ao1c05622_si_001.pdf (167.32 kB)
A Hyaluronic Acid-Based Formulation with Simultaneous Local Drug Delivery and Antioxidant Ability for Active Viscosupplementation
journal contribution
posted on 2022-03-15, 23:43 authored by Pooyan Makvandi, Francesca Della Sala, Mario di Gennaro, Nicola Solimando, Maurizio Pagliuca, Assunta BorzacchielloHyaluronic acid (HA) and its derivatives
are widely used for intra-articular
injection to augment compromised viscoelastic properties of damaged
synovial fluid. Combining HA-based devices with anti-inflammatory
drugs or bioactive principles in order to provide an additional benefit
to the viscosupplementation is emerging as a new promising approach
to improve the clinical outcome. Here, we aim to design a novel active
viscosupplementation agent that can load and release hydrophobic drugs
and at the same time possessing antioxidant properties. Optimized
ternary systems named HCV based on HA, (2-hydroxypropyl)-β-cyclodextrin
(CD), and vitamin E (VE), without being engaged in formal chemical
bonding with each other, showed the best viscoelastic and lubrication
properties along with antioxidant capabilities, able to solubilize
and release DF. The physical–chemical characterization suggested
that the HCV system displayed rheological synergism and higher thermal
stability because of the presence of VE and its antioxidant activity,
and the loading of hydrophobic drugs was improved by the presence
of CD and VE. Cell morphology and viability tests on L929 cells exhibited
high biocompatibility of the HCV system with higher level expression
of anti-inflammatory interleukin-10.
History
Usage metrics
Categories
Keywords
new promising approachlubrication properties alonghydroxypropyl )- βhigher thermal stabilityhigher level expressionformal chemical bondingdamaged synovial fluidrelease hydrophobic drugshydrophobic drugsrelease dfinflammatory drugswidely usedvitamin eviability testsinflammatory interleukinhyaluronic acidhcv systemclinical outcomecell morphologybioactive principlesbest viscoelasticbased formulationbased devicesarticular injectionantioxidant capabilitiesantioxidant activityantioxidant abilityadditional benefit), without