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A Highly Convergent and Biomimetic Total Synthesis of Portentol

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journal contribution
posted on 04.11.2015, 00:00 by Bichu Cheng, Dirk Trauner
An efficient total synthesis of the unusual polyketide portentol is reported. Three boron aldol reactions were used to assemble the linear carbon chain of the natural product, which contains two challenging antianti stereotriads. A biomimetic double cyclization cascade, triggered by an oxidation, then afforded portentol and its known dehydration product, anhydroportentol. The biosynthesis of portentol and the biosynthetic relevance of our key step are discussed.