ol7b01606_si_001.pdf (4.01 MB)
A General Strategy for the Construction of Functionalized Azaindolines via Domino Palladium-Catalyzed Heck Cyclization/Suzuki Coupling
journal contribution
posted on 2017-06-26, 23:29 authored by Tabitha
T. Schempp, Blake E. Daniels, Steven T. Staben, Craig E. StivalaThe preparation of substituted azaindolines
utilizing a domino
palladium-catalyzed Heck cyclization/Suzuki coupling is described.
The approach is amenable for the construction of all four azaindoline
isomers. A range of functional groups such as esters, amides, ketones,
sulfones, amines, and nitriles are all tolerated under the reaction
conditions.