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A General One-Step Synthesis of β-Nitronitriles

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journal contribution
posted on 18.09.2008, 00:00 by James C. Anderson, Alexander J. Blake, Matthew Mills, Paul D. Ratcliffe
The unusual β-nitronitrile functionality was prepared by a simple one-step hydrocyanation of nitroalkenes. These compounds were shown to be precursors to monoprotected 1,3-diamines and 1,3-amino alcohols through the in situ formation of an α-cyano-aldenyde.