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A General Method for the Enantioselective Synthesis of Pantolactone Derivatives

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journal contribution
posted on 07.09.2002, 00:00 by David A. Evans, Jimmy Wu, Craig E. Masse, David W. C. MacMillan
An efficient enantioselective synthesis of β,β-dialkyl-γ-substituted pantolactones has been achieved utilizing the cationic [Sc((S,S)-R-pybox)](Cl)2+, R = Ph (9), t-Bu (10), complex in a catalyzed aldol reaction as the key step. The pantolactone derivatives are isolated in high enantiomeric excesses.