posted on 2020-03-17, 11:39authored byShah Nawaz Khan, Muhammad Kashif Zaman, Ruining Li, Zhankui Sun
A general
and practical method for decarboxylative hydroxylation
of carboxylic acids was developed through visible light-induced photocatalysis
using molecular oxygen as the green oxidant. The addition of NaBH4 to in situ reduce the unstable peroxyl radical intermediate
much broadened the substrate scope. Different sp3 carbon-bearing
carboxylic acids were successfully employed as substrates, including
phenylacetic acid-type substrates, as well as aliphatic carboxylic
acids. This transformation worked smoothly on primary, secondary,
and tertiary carboxylic acids.