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A General Method for Convergent Synthesis of Polycyclic Ethers Based on Suzuki Cross-Coupling:  Concise Synthesis of the ABCD Ring System of Ciguatoxin

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journal contribution
posted on 14.09.1999, 00:00 by Makoto Sasaki, Haruhiko Fuwa, Makoto Ishikawa, Kazuo Tachibana
A general method for convergent assembly of polyether structure has been developed based on palladium(0)-mediated Suzuki cross-coupling reaction of alkylboranes with cyclic ketene acetal phosphates. The present method allowed for coupling of medium-sized ether rings and thus a concise synthesis of the ABCD ring system of ciguatoxins has been achieved.