A Facile Synthesis, In vitro and In vivo MR Studies of d-Glucuronic Acid-Coated Ultrasmall Ln2O3 (Ln = Eu, Gd, Dy, Ho, and Er) Nanoparticles as a New Potential MRI Contrast Agent
journal contribution
posted on 2011-09-28, 00:00 authored by Krishna Kattel, Ja Young Park, Wenlong Xu, Han Gyeol Kim, Eun Jung Lee, Badrul Alam Bony, Woo Choul Heo, Jae Jun Lee, Seonguk Jin, Jong Su Baeck, Yongmin Chang, Tae Jeong Kim, Ji Eun Bae, Kwon Seok Chae, Gang Ho LeeA facile one-pot synthesis of d-glucuronic acid-coated ultrasmall Ln2O3 (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles is presented. Their water proton relaxivities were studied to address their possibility as a new potential MRI contrast agent. We focused on the d-glucuronic acid-coated ultrasmall Dy2O3 nanoparticle because it showed the highest r2 relaxivity among studied nanoparticles. Its performance as a T2 MRI contrast agent was for the first time proved in vivo through its 3 T T2 MR images of a mouse, showing that it can be further exploited for the rational design of a new T2 MRI contrast agent at high MR fields.
