American Chemical Society
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A Facile Approach to the Synthesis of Chiral 2-Substituted Benzofurans

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journal contribution
posted on 2007-05-11, 00:00 authored by Lidia De Luca, Giampaolo Giacomelli, Giammario Nieddu
An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of α-alkyl-2-benzofuranmethanamines from N-protected α-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the help of microwave irradiation.