A Dual-Thermoresponsive Gemini-Type Supra-amphiphilic Macromolecular Pseudorotaxane Based on Pillararene/Paraquat Cooperative Complexation
journal contributionposted on 2016-02-10, 00:00 authored by Xiaodong Chi, Guocan Yu, Li Shao, Jianzhuang Chen, Feihe Huang
Herein, first we report the preparation of a thermoresponsive pseudorotaxane from cooperative complexation between a water-soluble pillararene and a paraquat derivative in water. Then we successfully construct the first pillararene-based gemini-type supra-amphiphilic pseudorotaxane from the water-soluble pillararene and a paraquat-containing poly(N-isopropylacrylamide) based on this new molecular recognition motif in water. This macromolecular pseudorotaxane shows unique dual-thermoresponsiveness. Furthermore, it can self-assemble into polymeric vesicles at 37 °C in water. These vesicles can be further used in the controlled release of small molecules induced by cooling to 25 °C or heating to 60 °C.