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A Direct and Versatile Access to α,α-Disubstituted 2-Pyrrolidinylmethanols by SmI2-Mediated Reductive Coupling

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journal contribution
posted on 17.07.2008, 00:00 by Olga N. Burchak, Christian Philouze, Pierre Yves Chavant, Sandrine Py
Various α,α-disubstituted 2-pyrrolidinylmethanols are efficiently prepared in a single step from ketones using a SmI2-mediated cross-coupling with 1-pyrroline N-oxide. The N-hydroxy-α,α-diphenylprolinol is also easily prepared and resolved.