American Chemical Society
ol101346w_si_002.pdf (2.12 MB)
Download file

A Direct Synthesis of Oxazoles from Aldehydes

Download (2.12 MB)
journal contribution
posted on 2010-08-20, 00:00 authored by Thomas H. Graham
An expedient method for the direct conversion of aldehydes to 2,4-disubstituted oxazoles is presented. The method relies on the oxidation of an oxazolidine formed from the condensation of serine with an aldehyde and proceeds through a 2,5-dihydrooxazole intermediate. In contrast to standard methods that start from carboxylic acids, the use of aldehydes as starting materials does not require intermediate purification and affords the oxazoles under relatively mild conditions.