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A,D-seco-Limonoids from the Stems of Clausena emarginata

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journal contribution
posted on 25.04.2014, 00:00 by Hong-Min Xia, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Xiao-Guang Chen, Dan Zhang, Li Li, Dong-Ming Zhang
Twelve new A,D-seco-limonoids, clauemargines A–L (112), and three known analogues were isolated from the stems of Clausena emarginata. The absolute configurations of 1 and 5 were confirmed by X-ray crystallography and ECD spectroscopy, respectively. Compounds 1, 2, 810, and 13 showed moderate inhibitory effects on LPS-induced NO production (IC50 values < 10 μM).