A Copper-Catalyzed Petasis
Reaction for the Synthesis
of Tertiary Amines and Amino Esters

Frauenlob, Robin; García, Carlos; Bradshaw, Gary A.; Burke, Helen M.; Bergin, Enda

doi:10.1021/jo3003503.s001

A Copper-Catalyzed Petasis Reaction for the Synthesis of Tertiary Amines and Amino Esters

journal contribution

posted on 2012-05-04, 00:00 authored by Robin Frauenlob, Carlos García, Gary A. Bradshaw, Helen M. Burke, Enda Bergin

We have developed a copper-catalyzed process for the coupling of aldehydes, amines, and boronic acids. This allows greater reactivity with simple aryl boronic acids and allows coupling reactions to proceed that previously failed. Initial mechanistic studies support a process involving transmetalation from boron to copper.