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A Convenient Route to Enantiomerically Pure 2-Substituted Methyl Glycerate Derivatives

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journal contribution
posted on 27.11.2003, 00:00 by Steven V. Ley, Patrick Michel, Claudio Trapella
The lithium enolate of a butanediacetal-protected glycerate derivative undergoes efficient and diastereoselective alkylation to afford a new fully substituted stereogenic center. These compounds may be elaborated to stable 2-substituted glyceraldehyde derivatives.