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A Concise Total Synthesis of the Lichen Macrolide (+)-Aspicilin

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journal contribution
posted on 26.10.2006, 00:00 by Christophe Dubost, István E. Markó, Thomas Ryckmans
The total synthesis of the polyhydroxylated macrolide (+)-aspicilin 5 is described using as a key step a highly diastereoselective allylation of aldehyde 6 with the uniquely functionalized allylstannane 1. (+)-Aspicilin is obtained in 18 steps and 10% overall yield.