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A Concise Synthesis of All Four Possible Benzo[4,5]furopyridines via Palladium-Mediated Reactions

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journal contribution
posted on 01.06.2002, 00:00 by Wen Song Yue, Jie Jack Li
By taking advantage of the α- and γ-activation of chloropyridines as well as palladium-mediated reactions, all four possible benzo[4,5]furopyridine tricyclic heterocycles, benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine, are efficiently synthesized from 2-chloro-3-iodopyridine, 3-chloro-4-stannylpyridine, 4-chloro-3-iodopyridine, and 2-chloro-3-hydroxypyridine, respectively.