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A Concise Asymmetric Synthesis of Torcetrapib

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journal contribution
posted on 03.08.2007, 00:00 authored by Meritxell Guinó, Pim Huat Phua, Jean-Claude Caille, King Kuok (Mimi) Hii
Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.