jo8b00888_si_001.pdf (7.67 MB)
A Class of Amide Ligands Enable Cu-Catalyzed Coupling of (Hetero)aryl Halides with Sulfinic Acid Salts under Mild Conditions
journal contribution
posted on 2018-05-22, 00:00 authored by Jinlong Zhao, Songtao Niu, Xi Jiang, Yongwen Jiang, Xiaojing Zhang, Tiemin Sun, Dawei MaThe
amide derived from 4-hydroxy-l-proline and 2,6-dimethylaniline
is a powerful ligand for Cu-catalyzed coupling of (hetero)aryl halides
with sulfinic acid salts, allowing the formation of a wide range of
(hetero)aryl sulfones from the corresponding (hetero)aryl halides
at considerably low catalytic loadings. The coupling of (hetero)aryl
iodides and sodium methanesulfinate proceeds at room temperature with
only 0.5 mol % CuI and ligand, representing the first example for
Cu-catalyzed arylation at both low catalytic loading and room temperature.