American Chemical Society
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A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV‑2 in Cells

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journal contribution
posted on 2023-12-08, 21:03 authored by Xiaohong Sang, Juan Wang, Jiao Zhou, Yan Xu, Jing An, Arieh Warshel, Ziwei Huang
SARS-CoV-2 is the virus that causes the global pandemic of COVID-19. The main protease (Mpro) of SARS-CoV-2 is essential for viral infection and is one of the major therapeutic targets for COVID-19. Here, we report the design, synthesis, and biological characterization of a novel heterobifunctional small molecule that could effectively induce the degradation of SARS-CoV-2 Mpro and its drug-resistant mutants in HEK 293T cells, thus demonstrating a new alternative strategy for intervening with proteins important for this novel coronavirus.