A Catalytic
Intermolecular Formal Ene Reaction between
Ketone-Derived Silyl Enol Ethers and Alkynes

Holmbo, Stephen
D.; Godfrey, Nicole A.; Hirner, Joshua J.; Pronin, Sergey V.

doi:10.1021/jacs.6b06847.s001

A Catalytic Intermolecular Formal Ene Reaction between Ketone-Derived Silyl Enol Ethers and Alkynes

journal contribution

posted on 2016-09-14, 00:00 authored by Stephen D. Holmbo, Nicole A. Godfrey, Joshua J. Hirner, Sergey V. Pronin

A catalytic formal ene reaction between ketone-derived silyl enol ethers and terminal alkynes is described. This transformation is uniquely capable of bimolecular assembly of 2-siloxy-1,4-dienes and can be used to access β,γ-unsaturated ketones containing quaternary carbons in the α-position.

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Ketone-Derived Silyl Enol Ethers terminal alkynes quaternary carbons siloxy Catalytic Intermolecular Formal Ene Reaction access ketone-derived silyl enol ethers 2-transformation assembly Alkyne ene reaction α- position

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CC BY-NC 4.0

A Catalytic Intermolecular Formal Ene Reaction between Ketone-Derived Silyl Enol Ethers and Alkynes

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